副研究員
心血管病是危害人類生命健康最嚴重的疾病之一，其患病率和死亡率均居各類疾病之首💋🏌🏼♀️。心血管病包括高血壓🧨、動脈粥樣硬化、腦卒中和心肌梗塞等，這些心血管病都有共同的發病學基礎和基本的病理過程，表現為心血管細胞遷移🔚、肥大💭、增殖和凋亡等👰🏿♂️，具有細胞表型🥳、形態結構與功能的改變，即發生血管重建。本實驗室研究要從基因－蛋白－細胞－器官－整體不同層次上綜合探討血管重建機製👆，研究心血管力學信號轉導通路與血管活性物質的功能及其分子網絡調控機製💜。近年來🧞♂️，我更關註非編碼RNA在高血壓和靜脈移植等疾病模型中的作用🐈⬛。
Yao QP, Liu Z, Yao AH, Liu JT, Jiang J, Chen Y, Li SS, Han Y, Jiang ZL, Qi YX*. Circular RNA CircTET3 mediates rat vascular smooth muscle cell migration by targeting miR-351-5p, Journal of Cellular Physiology, 2020; doi: 10.1002/jcp.29577
Xie ZW, Chen YX, Long CF, Qi YX, Yao QP*. Cyclic stretch induces VEGFA alternative splicing via Serine/Arginine-Rich Splicing Factor 1.Cell Mol Biol (Noisy-le-grand). 2018; 64(7):43-50.
Bao H, Chen YX, Huang K, Zhuang F, Bao M, Han Y, Chen XH, Shi Q, Yao QP*, Qi YX*. Platelet-derived microparticles promote endothelial cell proliferation in hypertension via miR-142-3p. FASEB J. 2018; 32(7):3912-3923.
Qing-Ping Yao, Zhiwei Xie, Kaixuan Wang, Ping Zhang, Yue Han, Ying-Xin Qi*, Jiang Zong-Lai. Profiles of lncRNAs in Hypertensive Rats: Long non-coding RNA XR007793 Regulates Cyclic Stretch-induced Vascular Smooth Muscle Cell Proliferation and Migration. Journal of hypertension, 2017; 35(6):1195-1203.
Qing-Ping Yao#, Ying-Xin Qi#, Ping Zhang, Bin-Bin Cheng, Zhi-Qiang Yan*, Zong-Lai Jiang. SIRT1 and Connexin40 Mediate the Normal Shear Stress-Induced Inhibition of the Proliferation of Endothelial Cells Co-Cultured with Vascular Smooth Muscle Cells. Cellular Physiology and Biochemistry, 2013; 31(2-3):389-399.
Yao QP, Hayman DM, Dai Q, Lindsey ML, Han HC, Alteration of Pulse Pressure Stimulates Arterial Wall Matrix Remodeling, Journal of Biomechanical Engineering. 2009; 131(10):101011.
Shi Q, Zhuang F, Liu JT, Li N, Chen YX, Su XB, Yao AH, Yao QP, Han Y, Li SS, Qi YX* & Jiang ZL. Single-cell analyses reveal functional classification of DCs and their potential roles in inflammatory disease. FASEB Journal. 2018, doi:10.1096/fj.20101489R.
Kai Huang, Han Bao, Zhi-Qiang Yan, Lu Wang, Ping Zhang, Qing-Ping Yao, Qian Shi, Xiao-Hu Chen, Kai-XuanWang, Bao-Rong Shen, Ying-Xin Qi*, and Zong-Lai Jiang . MicroRNA-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the graft vein. Cardiovascular Research. 2017; 113(5):488-497.
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