閆武鵬

長聘教軌副教授

  • 電話:+86-
  • 郵箱:yanwupeng@sjtu.edu.cn
  • 地址:上海市東川路800號EON体育4生命EON44號樓202室
  • 閆武鵬博士,博士生導師🧑。本課題組的研究方向主要集中於使用生物化學、生物物理以及結構生物學等手段研究酶功能、蛋白工程🧚🏼‍♀️、癌基因RAS和其下遊信號蛋白的功能調控以及相關抗癌藥物研發🏂🏻。從而在基礎和應用兩個方向解決相關科研問題🤧。

學術經歷

  • 教育經歷:

2017.4-2020.11  美國弗雷德裏克癌症研究國家實驗室, 博士後🌩、助理研究員II🫲🏿。

2016.4-2017.3    美國得克薩斯大學奧斯汀分校,博士後。

2009.8-2016.3    美國得克薩斯大學奧斯汀分校,生物化學♜,博士。

2004.8-2008.7    清華大學👆🏼,生物科學與技術系,學士💽。

 

  • 工作經歷:

2020.12-迄今     EON体育4🦵,長聘教軌副教授👩‍🦯。

研究方向

基於結構的抗癌藥物研發與改進

                     

 

蛋白工程

                     

癌基因RAS與其上下遊信號蛋白的功能調控以及相關抗癌藥物...

           

 

代表論著

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    Wang, X.*, Hu, S.*, Wang, J.*, Zhang, T.*, Ye, K., Wen, A., Zhu, G., Vegas, A., Zhang, L.#, Yan, W.# , Liu, X#. and Liu, P#. (2023) Biochemical and Structural Characterization of OvoA Th2: A Mononuclear Nonheme Iron Enzyme from Hydrogenimonas thermophila for Ovothiol Biosynthesis. ACS Catalysis, 13, pp.15417-15426.

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    Ge, X.*, Long, Y.*, Wang, J.*, Gu, B., Yang, Z., Feng, Y., Zheng, S., Li, Y., Yan, W.#and Song, H.# (2023) Regulation of P450 TleB catalytic flow for the synthesis of sulfur-containing indole alkaloids by substrate structure-directed strategy and protein engineering. Science China Chemistry, pp.1-10.

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    He, Y., Li, S., Wang, J., Yang, X., Zhu, J., Zhang, Q., Cui, L., Tan, Z., Yan, W., Zhang, Y. and Tang, L., et.al. (2023) Discovery and Engineering of the l-Threonine Aldolase from Neptunomonas marine for the Efficient Synthesis of β-Hydroxy-α-amino Acids via C–C Formation. ACS Catalysis, 13, pp.7210-7220.

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    Zhu, Guoliang*, Wupeng Yan*, Xinye Wang*, Ronghai Cheng*, Nathchar Naowarojna, Kun Wang, Jun Wang et al. (2022) Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues. JACS Au . https://doi.org/10.1021/jacsau.2c00248

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    Yan, W.,* Markegard, E.*, Dharmaiah S., Urisman A., Drew M., Esposito D., Scheffzek K., Nissley D., McCormick, F.* and Simanshu, D.K.* (2020) Structural insights into the SPRED1-neurofibromin-KRAS complex and disruption of SPRED1-neurofibromin interaction by oncogenic EGFR. Cell Reports, 32(3), 107909

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    Yan, W., Georgiou, G., Stone, E. and Zhang, Y. (2017) Structural rationale for the salt-dependence of engineered cystathionine- γ-lyase for methionine depletion. Biochemistry. 56 (6), 876-88

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    Lu W.C.*, Saha A.*, Yan W., Garrison K., Pandey R., Irani S., Tiziani S., Zhang Y.J., Georgiou G., DiGiovanni J., and Stone E. (2020) Enzyme-Mediated Depletion of Serum L-Met Abrogates Prostate Cancer Growth via Multiple Mechanisms without Evidence of Systemic Toxicity. PNAS, 117(23), 13000-13011.

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    Lee, C. H.*, Romain, G.*, Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee J., Triplett, K.,et al. (2017). IgG Fc Domains that bind C1q but not effector Fc gamma receptors delineate that significance of complement-mediated cell cytotoxicity and phagocytosis in antibody function. Nature Immunology. 18 (10), 1173-1173

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    Cramer, S.*, Saha, A.*, Tadi, S.*, Tiziani, S., Yan, W., Triplett, K., Lamb, C., Alters, S., Johnson, D., Zhang, Y., DiGiovanni, J., Georgiou, G.*, and Stone, E.* (2016). Systemic depletion of serum L-Cyst(e)ine with an engineered human enzyme induces production of reactive oxygen species and suppresses tumor growth in mice. Nature Medicine. 23, 120–127

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