長聘教軌副教授
基於蛋白質功能設計，在微納結構中整合具有分子特異性的生物電化學界面👖，實現低維狀態下生-電信號的實時交互。
利用蛋白質設計手段，通過解析在生理和病理過程中具有重要作用的膜蛋白的分子機製，或是設計類抗體誘餌受體蛋白，拓寬其在生物醫藥中的應用🤍。
利用包括擴散模型在內的深度學習方法，基於序列和結構等多方面信息進行基於結構的從頭蛋白設計或針對已有蛋白質數據集的性質優化。
利用包括QTY編碼在內的理性設計手段🧗🏻♂️，對於膜蛋白的溶解度和功能特性進行設計優化。
R. Qing|*, M. Xue|, J. Zhao, L. Wu, A. Breitwieser, E. Smorodina, T. Schubert, G. Azzellino, D. Jin, J. Kong, T. Palacios*, U. Sleytr, S. Zhang*. “Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays”, Science Advances, 9, 29, (2023) eadf1402.
R. Qing*, S. Hao*, E. Smorodina, D. Jin, A. Zalevsky, S. Zhang. “Protein Design: From the Aspect of Water Solubility”, Chemical Reviews, 122, 18, (2022) 14085-14179.
R. Meng, S. Hao*, C. Sun, Z. Hou, Y. Hou, L. Wang, P. Deng, P. Deng, J. Deng, Y. Yang, H. Xia, B. Wang*, R. Qing*, S. Zhang*. “Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice”, Proceedings of the National Academy of Sciences, 120, 21, (2023) e2220173120.
R. Qing*, Q. Han, M. Skuhersky, M. Badr, H. Chung, T. Schubert, S. Zhang*. “QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity”, Proceedings of the National Academy of Sciences, 116-51, (2019) 25668-25676.
R. Qing|*, F. Tao|, P. Chatterjee|, G. Yang, Q. Han, H. Chung, J. Ni, B. Suter, J. Kubicek, B. Maertens, T. Schubert, C. Blackburn, S. Zhang*. “Non-full-length water-soluble CXCR4QTY and CCR5QTY chemokine receptors: implication for overlooked truncated but functional membrane receptors”, 23-12, iScience, (2020) 101670.
L. Chen, R. Meng, R. Qing, W. Li, Z. Wang, Y. Hou, J. Deng, W. Pu, Z. Gao, B. Wang, S. Hao*. “Bioinspired Robust Keratin Hydrogels for Biomedical Applications”, Nano Letters, 22, 22, (2022) 8835-8844.
S. Hao, D. Jin, S. Zhang*, R. Qing*. “QTY code designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands”, QRB Discovery, 1-18, (2020).
P. Chatterjee*, N. Jakimo, J. Lee, N. Amrani, T. Rodriguez, S. Koseki, R. Qing, S. Hao, E. J. Sontheimer, J. M. Jacobson*. “An engineered ScCas9 with broad PAM range and high specificity and activity”, Nature Biotechnology, 38-10, (2020) 1212.
R. Qing, W. Sigmund*. “Bi-functional CexZr1−xO2 semiconductor nanoparticles with UV light switch”, Journal of Photochemistry and Photobiology A: Chemistry, 266, (2013) 55-63.
S. Zhang*, F. Tao, R. Qing, H. Tang, M. Skuhersky, K. Corin, L. Tegler, A. Wassie, B. Wassie, Y. Kwon, B. Suter, C. Entzian, T. Schubert, G. Yang, J. Labahn, J. Kubicek, B. Maertens. “QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities”, Proceedings of the National Academy of Sciences, 115-37, (2018) E8652-E8659.
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