劉然

副研究員

  • 電話😺:
  • 郵箱:l_ran@sjtu.edu.cn
  • 地址🩷:EON体育4平台4號樓B座

學術經歷

  • 2006.9—2010.6,四川農業大學🛋,生命科學與理EON4,生物科學專業,本科
  • 2010.9—2012.6,武漢大學🧚🏽‍♀️,藥EON4🌗,微生物與生化藥學專業,碩士
  • 2016.9—2020.6🧏🏿‍♀️,武漢大學🤜🏼,藥EON4🏄🏽‍♀️,生物化學與分子生物學專業,博士
  • 2020.9—2024.3,中國科EON4深圳先進技術研究院,合成生物學研究所,副研究員
  • 2024.4—至今,    EON体育4⚈,EON体育4平台🥯,副研究員

研究方向

微生物代謝與人體互作

1. 研究微生物代謝途徑或產物如何通過影響人體代謝物水平☢️、刺激人體免疫調節等機製影響宿主生理功能🐩。

2. 研究微生物代謝產物在疾病診斷、預防和治療中的潛在應用,如通過益生菌等幹預手段改善宿主健康。

利用微生物實現天然產物高產

利用合成生物學、代謝工程等多種技術實現微生物合成多種高價值天然產物🏊🏽‍♂️,並提升其產量。

代表論著

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    Liu R, Luo Z, Dai C, Wei Y, Yan S, Kuang X, Qi K, Fu A, Li Y, Fu S, Ma Z, Dai W, Xiao X, Wu Q, Zhou H, Rao Y, Yuan J, Shi T, Deng Z*, Chen C*, Liu T*. Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis. Signal Transduction and Targeted Therapy. 2024, 9(1):292.

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    Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T*. A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo. Advanced Science. 2020, 7(17):2001616. 

    •  

    Li D#, Liu R#, Wang M#, Peng R#, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z*, Wang G*, Li Y*, Liu T*.3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host & Microbe. 2022, 9;30(3):329-339

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    Yan P#, Wang G#, Huang M#, Liu Z, Dai C, Hu B, Gu M, Deng Z, Liu R*, Wang X*, Liu T*. Combinatorial Biosynthesis Creates a Novel Aglycone Polyether with High Potency and Low Side Effects Against Bladder Cancer. Advanced Science. 2024, 11(32):e2404668. 

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    Duan Y#, Fang F#, Mu X, Wang H, Shen Z, Deng Z, Liu T, Wang Z*, Liu R*. Exploration of Streptomyces fradiae J1-021 as a potential host for the heterologous production of spinosad. Journal of Agricultural and Food Chemistry. 2024, 72, 16, 8983–8992

  • •  

    Hu B#, Liu R#, Tang X#, Pan Y#, Wang M#, Tong Y#, Ye G#, Shen G#, Ying R, Fu A, Li D, Zhao W, Peng J, Guo J, Men D, Yao X, Wang Y, Zhang H, Feng Z, Yu J, Chen L, Deng Z, Lu X, Zhang YP*, Li Y*, Liu B*, Yu L*, Li Y*, Lu J*, Liu T*. The concordance between the evolutionary trend and the clinical manifestation of the two SARS-CoV-2 variants. National Science Review. 2021, 8(8):nwab073.

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    Mu X, Lei R, Yan S, Liu R*, Liu T*. The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa.  Synthetic and Systems Biotechnology. 2024, 9 (4): 609-617

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    An Z#, Tao H#, Wang Y, Xia B, Zou Y, Fu S, Fang F, Sun X, Huang R, Xia Y, Deng Z, Liu R*, Liu T*. Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton.Synthetic and Systems Biotechnology. 2021, 6(4):292-301.

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    Liu R#, Yu D#, Deng Z, Liu T*. Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM). Current Opinion in Biotechnology. 2021, 69:1-9. 

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    Liu R, Deng Z, Liu T*. Streptomyces species: Ideal chassis for natural product discovery and overproduction. Metabolic Engineering. 2018, 50:74-84.

獲獎情況

  • 2022年🫓,獲第七屆中國科學技術協會青年人才托舉工程
  • 2019年🐍,獲湖北省科技進步獎一等獎👱🏻‍♂️,《生物基法尼烯為前體合成維生素E的創新工藝》(第8位主要完成人)
  • 原料藥工業菌種改造關鍵技術及產業示範, 國家重點研發計劃,子課題負責人,2021-01--2024-12
  • 理性代謝改造泰樂菌素工業生產菌實現多殺菌素的異源高效合成🧞,國家自然科學基金青年基金👱‍♂️,項目負責人 ,2022-01--2024-12
  • 第七屆中國科學技術協會青年人才托舉工程🙏🏼👮🏽,項目負責人🫓, 2022-01--2024-12

承擔項目

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