教授/長聘副教授
多殺菌素(殺蟲)、紅黴素(抗細菌)、泰樂菌素(抗細菌)🏛👨🏻🦲、納他黴素(抗真菌)等抗生素大品種生產菌株的高產育種和理性改良➾✋🏻；新抗生素的高產菌種研製🔁。
鏈黴菌、擬無枝酸菌和糖多孢菌等細菌底盤的基因組編輯與人工進化。
沉默的天然產物基因簇的高效激活🧎♀️➡️🚵🏿♂️；新結構、新活性化合物的分離鑒定；微生物天然產物生物合成途徑的解析；化合物的組合生物合成等。
Genome-wide mutagenesis links multiple metabolic pathways with actinorhodin production in Streptomyces coelicolor. Xu Z*, Li Y, Wang Y, Deng Z, Tao M*. Appl Environ Microbiol, March 2019, 85(7). e03005-18. doi: 10.1128/AEM.03005-18.
Engineered Streptomyces lividans strains for optimal identification and expression of cryptic biosynthetic gene clusters. Peng Q, Gao G, Lü J, Long Q, Chen X, Zhang F, Xu M, Liu K, Wang Y, Deng Z, Li Z*, Tao M*. Front Microbiol. Dec. 2018, 9:3042. doi: 10.3389/fmicb.2018.03042.
Biosynthesis of tropolones in Streptomyces spp: interweaving biosynthesis and degradation of phenylacetic acid and hydroxylations on tropone ring. Chen X, Xu M, Lü J, …Lin S, Deng Z, Tao M*. Appl Environ Microbiol, 2018, doi: 10.1128/AEM.00349-18.
Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement. Gao G, Liu X, Xu M, … Jiang M,* Lin S.* Tao M*. Cell Chem Biol, 2017, 24:881-891.
Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy. Wang Y, Tao Z, Zheng H, Zhang F, Long Q, Deng Z, Tao M*. Metab Eng, 2016, 38:418-426.
Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp. Xu M, Wang Y, Zhao Z, … Pang X, Deng Z, Tao M*. Appl Environ Microbiol, 2016, 82:5795-5805.
Hybrubins: bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes. Zhao Z, Shi T, Xu M, … Deng Z, Pang X*, Tao M*. Org Lett, 2016, 18:572-575.
A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in Streptomyces. Xu H, Chater K F, Deng Z, and Tao M*. Journal of Bacteriology, 2008, 190(14): 4971-4978.
A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater K F, and Tao M*. FEMS Microbiology Letters, 2007, 266(1): 20-28.
論文下載
支撐材料