• Han Xiao

    Research Professor

    • Tel: +86-021
    • Email: smallhan@sjtu.edu.cn
    • Address: Bio-building #3-317, 800 Dongchuan Road, Shanghai, 200240, China

    Selected Publications

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      Yuhuan Luo, Jian-Jiang Zhong* and Han Xiao* (2025). Mechanism and engineering of endoplasmic reticulum-localized membrane protein folding in Saccharomyces cerevisiae. Metab Eng, 90: 43-56. 

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      Yuhuan Luo, Zeqian Du, Chenjian Jiang, Ziqian Yu, Jian-Jiang Zhong*, Ting Shi* and Han Xiao* (2023). Rational engineering of a membrane-anchored promiscuous cytochrome P450 for efficient biosynthesis of valuable ganoderic acids. ACS Catal, 13: 15673-15681.

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      Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang* and Han Xiao* (2022). Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast. Nat Commun, 13: 7740.

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      Yubo Fang and Han Xiao* (2022). The aspartic protease Yps3p and cell wall glucanase Scw10p are novel determinants that enhance the secretion of the anti-tumor triterpenoid GA-HLDOA in Saccharomyces cerevisiae. ACS Synth Biol, 11(9):2917-2926.

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      Chen Zhao, Qin Wang, Shaozhong Chang, Shuo Zhang, Zhonghua Li, Zihan Shen, Xin Jin, Han Xiao* and Huigang Zhang* (2022). Efficient transport system of cultivated mushroom mycelium enables its derived carbon with high performance electrochemical desalination capability. Carbon, 196: 699-707.

    • •  

      Pingan Wang, Han Xiao* and Jian-Jiang Zhong* (2020). CRISPR-Cas9 assisted functional gene editing in the mushroom Ganoderma lucidum. Appl Microbiol Biotechnol, 104: 1661-1671.

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      Xiaoting Lan, Wei Yuan, Meng Wang* and Han Xiao* (2019). Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase. Biotechnol Bioeng, 116(12): 3301-3311.

      •  

      Han Xiao*, Yue Zhang and Meng Wang* (2019). Discovery and engineering of cytochrome P450s for terpenoid biosynthesis. Trends Biotechnol, 37(6): 618-631.

      •  

      Wen-Fang Wang, Han Xiao* (co-first author) and Jian-Jiang Zhong* (2018). Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum. Biotechnol Bioeng, 115(7): 1842-1854.

      •  

      Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang and Huimin Zhao* (2018). Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnol, 36(6): 505-508.

    Students

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