主講人簡介：

陳玲玲，核糖核酸功能與應用重點實驗室主任，中國科EON4分子細胞科學卓越創新中心研究員，國家基金委傑青，首屆新基石研究員，首屆上海傑出人才。擔任中國科EON4B類先導專項、國家重點研發計劃等項目的負責人。受邀擔任Cell🏄🏻‍♂️、Science💷、Mol Cell等期刊的編委；擔任知名國際學術會議的大會主席，包括國際RNA學會、美國冷泉港實驗室、冷泉港亞洲、Keystone會議、美國實驗生物學會等。受邀百余次在國際知名學術會議以及知名學術機構做主旨報告和特邀報告。

長期從事核糖核酸（RNA）生物學研究，創建並利用新技術體系👉🏼，發現環形RNA、sno-lncRNA🤞🏻、SPA等RNA家族🧶，在揭示其生成規律🌠、生物學功能以及與人類疾病的關聯等方面取得了多項成果，為相關轉化應用提供了理論基礎。相關成果以通訊作者發表於Cell、Nature🤠、Science等80余篇，共發表論文百余篇，引用>3萬次。獲國際RNA學會科研中期成就獎💇🏿‍♀️、HHMI國際研究學者、FAOBMB卓越研究獎🪞、中國青年科技獎特別獎🧑🏿‍⚕️、中國青年女科學家獎、科學探索獎等學術獎勵🫸🏽。“環形RNA生成和功能機製的研究”獲國家自然科學獎二等獎（第一完成人）。

報告摘要：

Long noncoding RNAs (lncRNAs) are emerging as new regulators in gene expression networks and exhibit a surprising range of shapes and sizes. Many lncRNAs are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced like mRNAs. By developing methods for genome-wide discovery and characterization of non-polyadenylated RNAs, we have identified several RNA species with unexpected formats. These RNAs are derived from long primary transcripts via unusual RNA processing pathways and are stabilized by different mechanisms, including capping by small nucleolar RNA (snoRNA)–protein (snoRNP) complexes at their ends, and forming circular structures. We have shown that some such RNAs are involved in gene regulation through distinct mechanisms and are also implicated in human diseases. I will discuss our recent findings of underlying mechanisms related to their formation, subcellular localization and function.