講座時間：2019-5-9 14:00-15:30

講座地點：閔行校區生物藥學樓樹華多功能廳

主 講 人👊🏻🪇：李海濤 清華大學結構生物學高精尖創新中心副主任 教授

主辦單位👩🏼‍🎤👩🏿‍💻：EON体育4平台

聯 系 人：邢海娜 (xinghaina@sjtu.edu.cn)

主講人簡介：

李海濤🗳，清華大學醫EON4教授🧏。1997年山東大學本科畢業，2003年獲中科院生物物理所博士學位，同年赴美於紐約斯隆-凱特琳癌症中心從事博士後研究，2010年回清華大學任教。長期從事表觀遺傳調控的分子結構基礎研究，先後發現並闡明包括PHD、YEATS等在內一系列表觀遺傳調控因子識別或催化組蛋白修飾的分子基礎🧑‍🍳📀。目前在包括Nature, Cell在內的國際學術期刊發表論文或綜述70余篇，引用7800余次。先後獲得國家傑出青年基金🍨、藥明康德生命化學研究獎⚙️、人類前沿科學計劃青年研究員基金獎、茅以升北京青年科技獎🦛、清華大學學術新人📙，和教育部新世紀人才等榮譽或獎勵。

內容簡介🪳：

In eukaryotic organisms, access of genetic information is controlled by the “ON” or “OFF” state of chromatin. During the past decades, a remarkable variety of covalent modifications to histones or DNA have been documented. These chemical modifications provide vast indexing potential to the genome, and constitute an additional layer of epigenetic information, referred to as the “histone or epigenetic code” that regulate gene activity without alterations in the underlying DNA sequence. Chromatin modifications are under highly regulated forms of epigenetic control. Eukaryotic cells have evolved with counteracting enzymatic machineries for the “writing” or “erasing” of given epigenetic marks - distinct histone or DNA modifications. Meanwhile, a wealth of conserved “reader” modules have been created for specific recognition of these marks. Here, I report on the molecular basis underlying histone modification readout by the ever-expanding kingdom of reader modules, including Bromo, Tudor, PWWP, PHD, and YEATS domains. The examples presented here highlight how chromatin regulators make use of exquisitely designed reader modules to translate an epigenetic signature into downstream functional outcomes.

請感興趣的老師於2019年5月7日16:00之前報名👩🏼‍🦳。

報名方式💆🏽：

1.點擊以下網址

https://mp.weixin.qq.com/s/aL-yftz2y1DpwS11lW5pIQ

2.掃描下方二維碼報名