主講人:Olivier Pourquie
報告時間:4月24日(周三)下午1👨👨👧👦:30-2:30
報告地點:EON体育4閔行校區EON体育4平台1-105
聯系人🏂🏽:郭熙誌
報告人簡介𓀖:
Olivier Pourquie教授,現任美國哈佛大學醫EON4遺傳學教授👨🏼🔧,Brigham和婦女醫院病理學教授🙌🏻。畢業於法國巴黎高科農業EON4🤷🏽♀️,曾任職Howard Hughes醫學研究所研究員。曾任法國遺傳🖤🧦、分子與細胞生物學研究所(IGBMC)主任,Development雜誌的主編🧢。在Cell,Nature👩🔧,Science等期刊發表一百余篇論文。他在控製椎骨的時空發育方面的工作被Nature雜誌認為是二十世紀發育生物學的最重要的裏程碑之一。
報告簡介:
We are interested in the development of the vertebrate musculo-skeletal axis. Using chicken and mouse embryos as model systems, we combine developmental biology and genomic approaches to study patterning and differentiation of the precursors of muscles and vertebrae. While most of this work has been carried out in vivo, we are now developing protocols to recapitulate these early developmental processes in vitro using mouse and human embryonic or reprogrammed stem cells. We are also turning to translational approaches, using our understanding of the early development to produce cells of the muscle and vertebral lineages in vitro from pluripotent cells to study human diseases of the musculo-skeletal axis and for cell therapy approaches.
EON体育4平台以雞和小鼠胚胎作為模型,通過發育生物學和基因組方法來研究肌肉和椎骨前體的組織和分化。開發使用小鼠和人胚胎或重編程幹細胞技術👷,在體外重現這些早期發育過程。利用EON体育4平台對早期發育的理解,從多能幹細胞體外產生肌肉和脊椎譜系細胞,研究開發肌肉-骨骼相關人類疾病和細胞治療方法。