報告題目🫶🏼:Towards bacterial chemical glycobiology
報 告 人🚏:李學臣 教授 香港大學
報告時間: 3月30日,10:00-11:30
報告地點🐖:閔行校區生物藥學樓3-105會議室
聯 系 人👩🏻🎓:林雙君 linsj@sjtu.edu.cn
報告摘要:
To study proteins carrying post-translational modifications, chemical biology approach provides new tools to gain new insights to their biological significance. Over the year, we have developed novel methods to generate homogeneous proteins with site-specific modification structures and modify proteins. In particular, bacterial protein glycosylation has emerged as a new entry to study bacterial pathogenesis and develop novel therapeutic intervention. For instance, P. aeruginosa 1244 pilin is glycosylated with a trisaccharide and the exact biological function of Pse-containing glycans in bacterial glycoproteins remains elusive. In this presentation, we will report our efforts in developing chemical biology tools to study bacterial glycobiology.