報告題目: Mechanical Properties of Human Heart Trabeculae Carneae and its Effects on Diastolic Cardiac Function

報 告  人: 韓海潮（Hai-Chao Han）教授

報告時間: 7月12日（星期三）上午10時

報告地點: 閔行校區生物藥學樓 2號樓2-116會議室

聯 系  人：齊穎新，Tel: 34204863；email🤳🏻： qiyx@sjtu.edu.cn

摘  要: Trabeculae carneae are considered embryologic remnants that play no functional role in the adult heart. Thickening of the ventricular wall and the trabeculae carneae as well as fibrosis of trabeculae carneae occurs in LV hypertrophy but its role in cardiac function remains unclear. The objectives of our study are to characterize the mechanical properties of trabeculae carneae and determine the contribution of trabeculae carneae to the LV diastolic compliance. Our results demonstrated that trabeculae carneae is softer than the myocardium and cutting trabeculae carneae increases the LV compliance in human hearts. These results suggest that cutting LV trabeculae carneae could be a potential approach to treat patients with diastolic heart failure.

Information about graduate programs and opportunities at UTSA for graduate student exchange will be discussed.

講演人簡介：

韓海潮（Hai-Chao Han）教授，美國德克薩斯大學聖安東尼奧分校（UTSA）機械工程系系主任、Zachry特聘教授(Endowed Chair)。西安交通大學博士（與美國加州大學聖迭戈分校UCSD聯合培養）、美國佐治亞理工大學（Georgia Tech）生物醫學工程博士後🎞🛍。研究方向：心血管生物力學⚉。現任美國醫學與生物工程院會士（AIMBE Fellow）、美國機械工程學會會士（ASME Fellow）、美國心臟學會會士（AHA Fellow）🧑🏻‍⚕️，兼任美國ASME J Biomech Eng 副編輯（Associate Editor）和《醫用生物力學》編委等🧑🏽。曾獲美國NSF Career Award等獎勵。

e-mail: hai-chao han@utsa.edu

Short Bio.

Dr. Han is the Zachry Endowed Chair Professor and Department Chair of Mechanical Engineering at the University of Texas at San Antonio (UTSA). He received his Ph.D. degree in Solid Mechanics/Biomechanics in 1991 from Xi’an Jiaotong University in China with joint training from the University of California at San Diego under the tutelage of Professor YC Fung. Dr. Han was an Associate Professor at Xi’an Jiaotong University and a Research Engineer II at Georgia Institute of Technology before joining UTSA in 2003.

Dr. Han’s research interests are in the area of cardiovascular biomechanics with focus on arterial wall mechanical and instability, cardiac mechanics, and tissue remodeling. He has published over 100 peer-reviewed journal papers. He received a CAREER award from NSF in 2007. He is a Fellow of American Heart Association (AHA), College of Fellows of American Institute for Medical and Biological Engineering (AIMBE), and American Society of Mechanical Engineers (ASME). He is an Associate Editor of the ASME Journal of Biomechanical Engineering and a member of editorial boards of a number of journals.