報告題目：A new biotechnology paradigm shift – in vitro synthetic biology
報 告 人🙎‍♀️：Y-H Percival Zhang, Ph. D.
報告時間：2011年9月10日下午2點
報告地點：生物藥學樓3號樓403
組織單位🙍🏼：鐘建江實驗室
EON体育4平台
報告摘要🤹‍♀️：
The production of biofuels from renewable sugars isolated from plants or produced through artificial photosynthesis would provide a sustainable alternative for decreasing reliance on crude oil, mitigating greenhouse gas emissions, creating biomanufacturing jobs, and enhancing national energy security.   Since sugar costs usually account for at least 50% of biofuels’ selling prices, it is vital to produce desired biofuels with high product yields and at low production costs. However, it could be challenging to produce most advanced biofuels through microbial cell factories.   Here we suggest ultra-high-product yield and potentially low-cost biofuels production through cascade enzyme factories that can implement complicated biochemical reactions through in vitro assembly of stable enzymes and (biomimetic) coenzymes, called synthetic pathway biotransformation (SyPaB).  Great potential markets, include biodegradable sugar batteries, jet fuel, hydrogen, sugar hydrogen fuel cell vehicles, high-density electricity storage, and high efficiency production of starch, are motivating to solve remaining technical obstacles by using available technologies, such as protein engineering, enzyme immobilization, unit operations and system integration, etc.  The in vitro assembly of numerous enhanced performance and stable enzymes in one bioreactor that can last a very long reaction time (e.g., several months) would be an out-of-the-box solution for high-yield and ultra-low-cost biofuels production.  Also, the USA would have enough biomass resources (i.e., ~one billion ton per year) to replace all transportation fuel needs.
報告人簡介：
張以恒 (Y-H Percival Zhang) 是弗吉尼亞理工大學終身職位副教授。他生於中國武漢👬🏻，獲得上海華東理工大學本科和碩士學位。他師從生物能源研究先驅Lee.R.Lynd教授，在2002年於達特茅斯EON4獲得化學工程博士學位🧍‍♂️，自2005年起於弗吉尼亞理工大學任助理教授😱。目前科研著重於纖維素溶液為基礎的木質纖維素拆分，工程化纖維素酶，和體外合成生物學:合成酶途徑工程生產能源(例如:酒精、氫氣💪🏽↘️、電)🤑。他申請了十幾個專利🧖‍♂️，其中五個許可證已銷售給三個生物能源公司🎥。他發表了八十多篇文章，獲得包括Powe青年教授提高獎(2006)🤽🏻，美國空軍青年研究人員獎(2007)，杜邦青年教授(2008)，英國石油青年科學家(IBS2008)，弗吉尼亞理工大學年輕助理教授獎(2008)，Daniel IC Wang 獎(2009)在內的多個獎項，其研究進展受到廣泛報道，包括🈚️🙋🏽‍♀️：技術評論🌆、新科學家🧹、英國經濟學家、科學新聞🍛、美國商業周刊🏄、美國國家公眾廣播、德國明鏡周刊、美國化學會、英國皇家學會，等等🧑🏿‍🦳。其科研主要由美國能源部生物能源中心👨‍🎨、美國空軍科研辦、美國農業部🤷🏻‍♂️🧎🏻‍♀️‍➡️、美國國防部、美國化學會🕕、杜邦公司、殼牌石油等支持🔜。