報告題目：S-layer Proteins as Basic Building Blocks for Nanobiotechnological Applications

報告人：Prof. Uwe B.Sleytr

報告時間：2012.9.15 下午2▫️：00

報告地點👏：樹華多功能廳

聯系人：唐鴻誌

報告人簡介🧝🏿‍♂️：

Prof. Uwe B.Sleytr🧝，奧地利科EON4院士、美國紐約科EON4院士、歐洲科學與藝術EON4院士，奧地利自然資源與應用生命科學大學生物納米技術中心主任。

報告摘要：

Crystalline bacterial cell surface layer (S-layer) proteins have been optimized during billions of years of biological evolution as constituent elements of bacterial and archaeal cell envelopes. The broad application potential of S-layers in nanobiotechnology is based on the specific intrinsic features of the monomolecular arrays composed of identical protein or glycoprotein subunits. Most important physicochemical properties and functional groups on the protein lattice are arranged in well-defined positions. Many applications of S-layers depend on the capability of isolated subunits to reassemble into monomolecular arrays in suspension or on suitable surfaces (e.g. polymers, metals, silicon wafers) or interfaces (e.g. lipid films, liposomes, emulsomes). S-layers also represent a unique structural basis and patterning element for generating more complex supramolecular structures involving all major classes of biological molecules (e.g. proteins, lipids, glycans, nucleic acids or combinations of that). The biomimetic approach, copying the supramolecular building principle of S-layer-associated plasma membranes developed by archaea, offers manifold application potentials as far as to novel technologies for the generation of functional lipid membranes and biomimetic virus envelopes. Thus, S-layers fulfil key requirements as building blocks and patterning elements for the production of new supramolecular materials and nanoscale devices as required in molecular nanotechnology, nanobiotechnology, synthetic biology, and biomimetics.