報告題目：Using Caenorhabditis elegans and Escherichia coli to understand how microbes influence animal ageing

報告人🪞🪓：Dr. David Weinkove

School of Biological and Biomedical Sciences

Durham University,  United Kingdom

報告時間🍃：2012年9月24日上午10:00

報告地點：EON体育4生物藥學樓樹華多功能廳

聯系人：趙立平  021-34204878

Abstract:

The nematode worm C. elegans is a well established model organism used to answer fundamental questions in animal biology. In the lab, C. elegans is cultured on lawns of E. coli, a microbe derived originally from the human gut. We have discovered a mutant of E. coli that extends worm lifespan. This lifespan extension is caused by decreased folate synthesis in microbe. A sulphonamide drug that inhibits E. coli folate synthesis causes a dose-dependent increase in C. elegans lifespan without negative effects on either the microbe or the animal. Thus, this intervention may be transferable to more complex animals to slow ageing and improve health.

EON体育4平台

上海市微生物學會